Approaches to creativity and innovation in business Essay

Approaches to creativity and innovation in business - Essay Example Mint), Department of Justice (Federal Bureau of Prisons), Department of Energy (Brookhaven National Laboratory), NASA (Goddard Space Flight Center), Department of Veteran Affairs (Medical & Regional Office Centers), Department of Labor and various state and municipal agencies like City of Wilmington, Delaware, City of Tullytown, Pennsylvania and govt. of the District of Columbia. â€Å"We aim to achieve unequalled service delivery that meets or exceed our clients' expectations, caring for our environment and host communities in a friendly manner so as to create value to our clients, employees and the environment (ECG Indutries. Inc, 2012).† The mission statement of ECG industries, INC. encompasses all elements of their business. Their commitment to environment preservation while carrying out their operations is clearly demonstrated through their mission statement. Today’s business climate demands that special attention be paid to environmental services which are driven and heavily controlled by environmental regulations. There are many published guidance manuals and policies at Federal, state and local levels that regulate businesses. The number of regulations controlling businesses with respect to environmental concerns is constantly increasing by the day. The environmental laws are constantly evolving and the nature of these regulations is getting more complex than ever. For a business to operate successfully, they have to comply with all these regulations. Businesses like ECG need to incorporate in their operation a combination of project management skills, technical expertise, regulatory knowledge and experience in dealing with environmental concerns to deal effectively with the heavily regulated environment. Services offered by ECG have the potential of causing severe environmental degradation. They can affect the physical environment as well as health, culture and the economic and social structure of local and indigenous communities. ECG has to conform to environmental standards because of the wide variety of customers they serve. Not only do they have to conform to existing laws, they have to anticipate any changes that might occur and change themselves accordingly (Wawryk, 2012). As applies to ECG, guidelines and standards of International Association of Oil and Gas Producers and American Petroleum Institute can affect operations. The International Association of Oil and Gas producers represents oil and gas companies from all around the world where as the American Petroleum Institute majorly influences the oil and gas industry because of the dominance of American oil companies in the industry. Policies of the World Conservation union along with United Nation Environment Programmed, International Standards Organization, International Chambers of Commerce, the World Bank etc can also influence ECG. The guidelines prepared by the International Association of Oil and Gas Producers include practices that are international ly accepted. The 11 principles contained in the American Petroleum Institute Environmental and Safety Mission and Guiding principles form the basis the American Petroleum Institute environmental Stewardship Program. The American Petrol

Poor indoor air quality Essay Example | Topics and Well Written Essays - 250 words

Poor indoor air quality - Essay Example People spend majority of their time indoors and are exposed to numerous indoor contaminants / pollutants from other occupants (exhaled carbon dioxide, second hand smoke, perfume, body odors), building materials (gases, dusts, asbestos etc), furniture and fixtures (dust mites, vapors, gases), dampness (fungus, mould, bacteria) and cleaning agents used (toxic vapors, volatile toxic compounds). High or low level of humidity, improper ventilation, infiltration, lighting and noise also effect air quality. There are standard tests for gauging the air quality and remedies for improving IAQ to the set standards that verify good living condition for us. Poor IAQ can adversely affect health of a person which are summed up as a) Sick Building Syndrome (SBS): where health is adversely effected linked to how much time a person spends indoor yet the cause or illness cannot be identified, b) Multiple Chemical Sensitivities (MCS): where some might come under the effect, however medical opinion remai ns divided, c) Building-Related Illness (BRI): these are more serious yet less frequent cases with clinical symptoms proven linked to the IAQ, d) Environmental Tobacco Smoke (ETS): arises from passive smoking and increases the risk of coronary heart diseases (The International Agency for Research on Cancer IARC, 2002).

Application Of Molecular Genetics To Crops

Application Of Molecular Genetics To Crops The science of biotechnology is likely to be to the first half of the 21st century what the computer was to the second half of the 20th century. Its implications are profound, its potential benefits massive. Britain is well placed to keep our lead in Europe. I want to make it clear: we dont intend to let our leadership fall behind and are prepared to back that commitment with investment. are the words of Tony Blair at the European Bioscience Conference (November 2000) (cited in Francesca Tencalla, 2005), which is the best way to present my positive answer towards the question. The molecular genetics positively impacts the plant breeding paradigm. Introduction: Centuries ago, the science was unknown to the farmers but the present agricultural scenario is changing its traditional frame of conventional breeding to the most recent and modernized frame of molecular plant breeding. Today, the world agriculture is facing great challenges on four fronts visually, Production, Population, Pollution, and Politics. Also, the change in climate (global warming) is the next major challenge for the crops, as unlike animals they can not move from one place to another. The prospects for feeding humanity as we are in 21st century often are portrayed in a daunting light to keep pace with the population growth. As we are told that worlds population has been growing faster than crop production, since the early 1980s and is expected to be 8 billion in next or two decades. At this point, we need to think in-depth about the opportunities to meet these challenges and to improve the crop production at a subsequent rate. Are the agronomic practices merely going to pl ay the key role or the refined crop protection measures will be the major part of increase in crop production, at this junction of scientific development? No other than, molecular genetics and the application of molecular techniques to enhance the efficiency of plant breeding, will play the crucial role in crop improvement, is a promise to the next generations (Ben Miflin, 2000). At the turn of the 20th century, the discovery of principles of natural selection and hybridization by Darwin and the rediscovery of Mendelian genetics served as the basis for plant breeding and genetics. In the same way, tremendous increase in crop yields in the 21st century has been powered by the development of plant biotechnology, -omics era of molecular biology, and molecular genetics. The recent techniques of molecular genetics are emerging continuously to overcome the demand of growing population (Moose et al., 2008). The chief objective of molecular genetics is to enhance crop production and crop produce usefulness by genetic modification of crop plants; this is precisely what plant breeding has been doing from the day prehistoric man began to domesticate the orphan (wild) species. The molecular genetic techniques aim to give traditional breeding a technological boost, says Jorge Dubcovsky, a wheat molecular geneticist from University of California, whose group is presently working on Marker Assisted selection in wheat for 23 separate traits, conferring resistance to insect-pests, fungi and viruses. His enthusiastic claim is that this research could offer the wings for crop improvement to plant breeding what jet engine has brought to air travel. Basic Terms: Plant Breeding is an art as well as science of improving genetic makeup of plants in relation to their economic use (Paul et al., 2006; Singh B.D., 2003). Molecular genetics refers to the study of molecules, our genes, their structure and functions at molecular level. Also studies the transfer of genes from one generation to the next. It employs the principles of genetics and methods of molecular biology (NCBI, Wikipedia). Recently, Crop improvement is the science of value addition to the existing crop species by using the technique, which marries conventional plant breeding with molecular biology, to get theatrical gains in yield (Austin R.B., 1986). Hundred years of Genetics: (From domestication to transformation) Plant breeding deals with the aspect of crop production. In early days, plant breeding was mainly based on skills and the abilities of the breeder involved in the programme. But as the genetic engineering and the tools of molecular genetics were elucidated, breeding methods and programmes were designed in their light. Plant breeding began with the domestication, when primitive men cultivated the first crop for the benefit of mankind. Thereafter, the process of exploiting the crops for improvement of their commercial values has a long history in itself. As early as 700 B.C., Babylonians and Assyrians performed artificial pollination in date palm. Then, the first artificial hybrid named Fairchilds mule produced by Thomas Fairchild by crossing carnation with sweet William in 1717. These provide the clear evidence of plant breeding exist as an art before the discovery of Mendelian genetics. In 1900, the rediscovery of Gregor John Mendels paper provided the foundation for the vast knowledge of genetics for crop improvement. A noteworthy development resulted from the discoveries of G.H. Shull on inbreeding in maize (Zea mays), led to the production of hybrid varieties in maize, sorghum, cotton, rice and several other crops. Green Revolution, one of the greatest achievements in the modern plant breeding has been the introduction of dwarf gene in cereals, particularly in wheat (Triticum aestivum) and rice (Oryza sativa), (Borlaug, 2000). In 1960, Allozymes the first biochemical genetic markers were on hand. The next decade provided new tools to geneticists of restriction fragment length polymorphism (RFLP) and Southern blotting. Taq polymerase was found in 1980 and shortly Polymerase chain reaction was developed, which is now routinely used in plant breeding research. The recently developed technology is single nucleotide polymorphic markers based on high density DNA arrays, a technique known as Gene Chips (Rodomiro Ortiz, 1998). In 1980, the era of biotechnology began with the successful production of the first transgenic plant using Agrobacterium (Moose and Mumm, 2008). The methods of crop improvement have changed dramatically through last 25 years. The continued exploitation of biotechnology and the integration of genomic tools in crop improvement widen the plant breeding research. The novel genetic approaches like next generation sequencing (NGS), high-throughput marker genotyping, advanced-backcross QTL analysis, introgression libraries (ILs), multi-parent advanced generation intercross (MAGIC) population, can be harnessed to recognize the genetic variations within the crop species and between cultivated and wild species (Varshney et al., 2009). The seeds of molecular genetics are immensely sprouting and sooner will grow into a self-sufficient fruitful plant to alleviate the world hunger. Application and Impact of Molecular Genetics on Crop Improvement: The Father of Green Revolution, Dr. Norman Borlaug said in an interview: Biotechnology helps farmers produce higher yields on less land. This is a very environmentally favorable benefit. He justified his statement by giving the fact that the worlds grain output in 1950 was 692 million tonnes. After forty years or so later, the worlds farmers sown the crops in about the same acreage of land but they harvested 1.9 billion tonnes that counts the 170% increase in global production. To get this increased production in 1999 using the same conventional breeding, farmers would have needed an additional land of 1.8 billion hectares, instead of using 600 million as used in 1950 (www.actionbioscience.org). Opportunely, plant breeding research is at an arena where there are remarkable advances being made at molecular levels and these endow with opportunities to augment the molecular technologies available for crop improvement as outlined below. Distant hybridization: With the advancement of molecular genetics, it is now possible to transfer genes between distantly related plants. Now genes can be transferred interspecific and intergeneric. Recombinant DNA technology can be amplified to transfer the desirable genes from lower level organisms. For example, Progenies derived from rice (Oryza sativa ssp. japonica) plants pollinated by Oenothera biennis exhibited numerous morphological and developmental traits. Results from amplified fragment length polymorphism (AFLP) analysis showed that several rice lines contained extensive genetic variations, which included disappearance of rice parental bands and/or appearance of novel bands (Chu Xiu Chang et al., 2007). Recombinant DNA technology: There are two methods for crop improvement using r-DNA technology namely, direct and indirect methods. The direct method involves the introduction of novel gene(s) to crops by transformation outside the constraints of sexual crossing. Whereas, the indirect method involves the improving crops by the development of molecular markers (Miflin, CIHEAM). These methods have their specific significance in plant breeding so, are discussed as under. Molecular Markers for crop improvement: Molecular marker refers to the easily detectable marker linked to a desirable trait. The plant breeding analyses like, early generation selection, enrichment of complex F1 generation, choice of donor parent in backcrossing, recovery of recurrent parent genotype in backcrossing, linkage block analysis and selection, exploit molecular markers as a valuable tool. Application of molecular markers in plant breeding includes Germplasm characterization/fingerprinting, determining seed purity, systematic sampling of Germplasm, and phylogenetic analysis. Molecular markers played a key role in replacing bioassays (Varshney et al., 2008). Crop plants exhibit 20-50,000 genes, out of which only few are of our interest in crop improvement. Conventional linkage maps are based on these genes of interest which have distinct morphological effect. But there are limitations in such maps as they cannot map out the genes governing quantitative traits, are time consuming and tedious. Therefore, emphases were made to focus on molecular markers for linkage mapping. There are many types of molecular markers visually isozymes, restriction fragment length polymorphism (RFLP), randomly amplified polymorphic DNA (RAPD), cleaved amplified polymorphic sites (CAPS), simple sequence repeats (SSR), amplified length fragment polymorphism (AFLP), and the latest includes single nucleotide polymorphism (SNP) and single feature polymorphism (SFP), (Bertrand C. Y Collard and David J Mackill, 2008; Varshney et al., 2006). Out of these, SSR or microsatellite is the most widely used marker in major cereal crops (Bertrand C. Y Collard and David J Mackill, 2008). The SNP and DArT (diversity array technology) markers are other high-throughput markers, which can be used to prepare the whole genome map even without the availability of sequence data for the crop (Varshney et al., 2006). In recent years, noteworthy and stimulating progress has been made in marker assisted technology and the development of markers linked to the gene of interest. Some important achievements are given in table 1. Molecular Assisted Selection (MAS): MAS (figure 1) speed ups and makes conventional breeding easier as herein, linked molecular markers are used for indirect selection of desirable traits that were difficult to select earlier in seedling stage (Anushri Varshney et al., 2004). Jonathan et al., 1998, while performing their research on Musa found that due to its triploid nature, the highly relevant generation and the precise linkage maps is not usually attainable. So, to generate linkage map, they first generated traditional linkage map based on diploid relatives and extrapolation to the polyploidy crop and then did polyploidy mapping based on single dose markers in population derived from crosses between tetraploid and diploid genotypes. Thus, it became possible to generate the linkage map of current Musa, which is an allotetraploid. Bioinformatics: Bioinformatics is often overlooked side of molecular marker strategies. As we know that molecular technologies produces a large number of data, with great chances of error introduction during handling and interpretation. The correct accreditation of data is necessary for getting the precise results after a long run of experiments, so for maintaining that huge amount of data bioinformatics enabled such software that provide accurate results and are available through World Wide Web (Simmonds et al., 1999). Quantitative trait Loci (QTL): The most interesting use of molecular markers is the efficient selection of traits. They also made it possible to select polygenic traits controlled by QTLs, by the use of molecular markers like RFLPs and isozymes. Interesting work has been done on QTL by Tanksley et al., on tomatoes, Stuber et al., on maize, McCough and Doerge on rice and Bradshaw et al. on potatoes. The future research can be made in improving the disease resistance in cereal crops (Simmonds et al., 1999). Development of nodules in cereals: Leguminous plants have root nodules that contain nitrogen fixing bacteria known as Rhizobium. These bacteria fix atmospheric nitrogen in root nodules in the form of nitrates. If this gene can be transferred or active root nodules can be developed in cereal crops like wheat, rice, maize, sorghum, pearl millet, barley etc. thus, the reliability of crops on chemical fertilizers would be reduced leading to a significant reduction in cost of production as well as environmental pollution. The introduction of symbiotic biological nitrogen fixation into the major non-legume crops of the world would be one of the most significant contributions that biotechnology could make to agricultural sustainability. With this objective, Edward C. Cocking et al., studied the interaction of rhizobia with the root systems of cereals. They have already confirmed that some naturally occurring rhizobia, such as Parasponia species those isolated from root nodules of non-legume and Aeschynomene from stem nodules of tropical legume species, are able to enter the root systems of maize, rice and wheat by crack entry means the part of plant where lateral roots emerge through the root cortex, so it results to the both inter and intra cellular penetration of rhizobiain, particularly in the cortex of emerging lateral roots. In the recent study, they have interacted oxygen tolerant Azorhizobium caulinodans ORS571 (kindly donated by Dr J K Ladha, IRRI) isolated from stem nodules of the tropical legume Sesbania rostrata with the root systems of rice and wheat. We have found that intracellular invasion of cells of the cortex of roots of both rice (IR42 and Lemont) and wheat (Wembley) results in plants that are active in nitrogen fixation as determined using acetylene reduction assays (Edward C. Cocking et al.). The Plants for future: (Development of transgenic plants) Transgenic plant is the product of genetic engineering, with artificially inserted foreign gene (Adina Breiman and Esra Galun, 1997). The most important tool in plant biotechnology is the transgenic plant production. This technique requires the study of chromosome at molecular levels, genome sequencing and the identification, selection and then insertion of gene of interest form same species in modified form, or related wild species, unrelated species, genus, across kingdom or from microbes (bacteria, virus, fungi). The successful commercialization of first transgenic crop in 1996 is the remarkable achievement in plant breeding and biotechnology. In 2008, globally both the number of countries (25 countries are GM growers) as well as the number of farmers (13.3 million farmers) growing transgenic crops in 125 million hectares of land, has increased significantly (Table-2), (ISAAA web pages). This technology boosts yields, reduce pesticide usage, increase fertilizer efficiency, enhance disease, drought, pest, resistances to various crops. Recently, Sugarbeet RR herbicide resistant variety is grown in USA, gives significant positive results. Another milestone of transgenic breeding is GOLDEN RICE: genetically modified rice that contain bets carotene which can produce vitamin-A, once consumed (Potrykus, 2001). The production of golden rice presents a second green revolution, where certain countries will become the sole producers of major money making crop. It is believed that this would be the most dominating science in future that will play the most crucial role in the crop improvement and can satisfy the growing world hunger. Future prospects: We already have genetically modified crops for various interesting traits, which are developed so far generally involve only the addition of a single gene. Looking to the future, its unclear whether complex traits, which are thought to involve multiple genes, will be amenable to manipulation through genetic engineering (Jonathan Knight, 2003). All these techniques are costly and the research in public sectors is less due to lack of funds. There is the thrust of evolving the more precise, accelerating and cheaper molecular methods that can revolutionized the world agriculture. DNA chip technology and user friendly marker system are the evolving trends in future. For sustainable and self sufficient agriculture, we need carry out continuous efforts in positive direction. There should be the willingness to accept the research and research products globally, politically and socially as well. Then only we can expect second green revolution. Conclusion: We are at the stage of broad and rapid era of science development in all the fields. Time is ripe for the second green revolution which would not only concentrate on increased productivity but also on value added traits to reduce cost of production, pollution dangers and improved quality. Rapid development of plant biotechnology, particularly molecular genetics will serve as the basis for the second green revolution. To speed up the production process economically, to fulfill the aspirations of huge populace, to achieve diversification and adding value to the primary produce so as to make agriculture enterprise farmers as well as environmental friendly. Advanced technologies are expected to materialize many of our expectations in the 21st century. On the other hand, if we arrogantly enjoy the past but ignore the new challenges, or underestimates our capabilities and feel afraid of innovations like GM crops, it is possible that we miss the good opportunities, as said in this Chinese p roverb, Ninety miles is only the half way of a hundred-mile journey. Confucius once said: The passage of time is just like the flow of the river, which goes on day and night, forever. The past glories are the momentum for our new journey; the journey of science, journey of development, journey towards the state of self reliance, while the lessons from the past may teach us to be smarter. We need molecular genetics to make historic contributions to the rejuvenation of the plant breeding and thus the agriculture.

Trust Thy Self :: essays research papers

Trust ThySelf:  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  To believe your own thought, to believe that what is true for you in your private heart is true for all men, -- that is genius  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Your genuine action will explain itself, and will explain your other genuine actions. Your conformity explains nothing  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  A man should learn to detect and watch that gleam of light which flashes across his mind from within, more than the lustre of the firmament of bards and sages. Yet he dismisses without notice his thought, because it is his. In every work of genius we recognize our own rejected thoughts: they come back to us with a certain alienated majesty.  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Trust thyself: every heart vibrates to that iron string. Accept the place the divine providence has found for you, the society of your contemporaries, the connection of events. Great men have always done so, and confided themselves childlike to the genius of their age, betraying their perception that the absolutely trustworthy was seated at their heart, working through their hands, predominating in all their being. (Trust who and what you are)  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  No law can be sacred to me but that of my nature.  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  What I must do is all that concerns me, not what the people think  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  It is the harder, because you will always find those who think they know what is your duty better than you know it. It is easy in the world to live after the world's opinion; it is easy in solitude to live after our own; but the great man is he who in the midst of the crowd keeps with perfect sweetness the independence of solitude. (Peer Pressure)  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  The other terror that scares us from self-trust is our consistency; a reverence for our past act or word, because the eyes of others have no other data for computing our orbit than our past acts, and we are loath to disappoint them.  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  But perception is not whimsical, but fatal  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Man is timid and apologetic; he is no longer upright; he dares not say `I think,' `I am,' but quotes some saint or sage. (Given up on self)  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Insist on yourself; never imitate Except yourself:  ·Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  There is a time in every man's education when he arrives at the conviction that envy is ignorance; that imitation is suicide; that he must take himself for better, for worse, as his portion; that though the wide universe is full of good, no kernel of nourishing corn can come to him but through his toil bestowed on that plot of ground which is given to him to till.

History Of Multifocal Bone Infarctions Health And Social Care Essay

Osteonecrosis is a common complication of corticosteroid therapy. In this survey, we report the instance of a patient with injury of both articulatio genuss 1 twelvemonth back who has been diagnosed with knee osteonecrosis affecting bilateral proximal tibial and distal thighbone likely due to microvascular hurt to proximal shinbone and distal thighbone. A 22-year-old male patient presented with a history of writhing hurt of both articulatio genuss.He had non taken any drug, In malice of some anodynes, that leads to osteonecrosis. One twelvemonth subsequently, he developed bilateral anterior articulatio genus hurting of insidious oncoming. Magnetic resonance imagination performed on admittance showed osteonecrosis of the bilateral proximal tibial and distal thighbone, about every bit pronounced in the shinbone and thighbone. Osteonecrosis is a reasonably common complication in patients with the history of corticoid usage for the intervention of assortment of systemic and arthritic ups ets. The status can attest itself anyplace in the skeletal system, most normally in the femoral caput. Distal thighbone and proximal shinbone with bilateral engagement is rather rare in the literature. Injury of both articulatio genuss and within one twelvemonth gross osteonecrosis of bilateral articulatio genus articulation is rarest presentation. BONE INFARCTION: known by other names i.e. Avascular mortification, osteonecrosis, sterile mortification, ischaemic bone mortification and AVN ) is a disease due to break of blood supply of tissues, because of vascular via media, cellular decease of bone occur that leads to prostration. It is largely occur in the country where blood supply is unstable and by terminal arterias. It is largely occur at hip articulation but late there is increased opportunity of infarction in weight bearing country of articulatio genus articulation besides and leads to gross devastation of articular surfaces and whole articulations and ligaments. There are many theories about what causes avascular mortification. Hazard factors are chemotherapy in malignant neoplastic disease patient, long term usage of intoxicant and steroid, station injury, decompression illness, vascular via media due to arterial intercalation and thrombosis due to intimal harm, Radiation, prolonged usage of bisphosphonate in osteoporo sis, blood upsets, such as reaping hook cell disease, Glycogen storage upset i.e. Gaucher disease. Commonest is idiopathic. Systemic lupus erythematous, Rheumatoid arthritis, Prolonged, repeated exposure to high force per unit areas etc. So bone infarction can happen by two ways one is primary due to direct hurt of blood supply by child or terrible injury known as self-generated osteonecrosis of the articulatio genus ( SPONK ) , is ill understood but seems to be the consequence of some type of injury to the articulatio genus. It normally affects merely one articulatio genus and most frequently a individual country within the articulatio genus. The country of bone in the articulatio genus loses its normal blood supply and may finally weaken and prostration. This typically leads to trouble and functional restrictions. The hurting is frequently sudden oncoming and increases with weight bearing, step mounting, and at dark. SPONK is most frequently seen in aged adult females with osteopo rosis and secondrily due to drawn-out exposure of hazard factors, affect multiple countries of the articulatio genus, and 80 % of people have both articulatio genuss affected.Case HistoryA 22-year-old adult male with no important medical history presented after the one twelvemonth of in important history of injury complained of left articulatio genus hurting, which he noted after making difficult work and remainder and sometime without associated injury. Pain became worse at dark.He is holding a good scope of articulatio genus gesture bilaterally but terminally terrible painful. Initially he is able to his day-to-day modus operandis but after few old ages subsequently he is non able to make his modus operandi and progressive fatigues additions, musculus neglect wasting, and failing around the joint. He is besides holding history of ictuss for which he is taking intervention but the cause is non cleared because CT encephalon is normal. Everyday research lab scrutiny showed neutrophilia, thrombocytosis, with a hemoglobin degree of 11.3 g/dL, entire WBC count 14100, N 85 % , L 44 % , M 12 % , RBC 3.84, HCT 35 % , MCV 91 % , MCH 29.5pg, MCHC32.3g/dl, RDW14.8 % , ph4.58, MPV 7.7, PCT 0.35 % , PDW 16, and a elevated ESR 101.Periphral vilification shows no sickling. An MRI of the left articulatio genus showed increased ruddy bone marrow within the distal thighbone and proximal tibia/fibula, ab initio thought to be compatible with anaemia from an unexplained inflammatory procedure. Further urologic and gastro enterologic workup was negative. There is no history of steroid or other drug consumptions along with no any drawn-out exposure of hazard factors.Clinical Photograph:Degree centigrades: UsersuserPictures2013-02-15 14.26.49.jpg Fig ( 1 ) Bilateral articulatio genus with normal skin coloring material with same degree of kneecap with mild gush in left sideXRAY OF LEFT KNEEDegree centigrades: UsersuserPictures2013-02-15 13.59.11.jpgfig ( 2 ) : radiogram of bilateral articulatio genuss joint with decresed joint infinite with distal femur median compartment articular devolution with little addition denseness of median femoral articular border.MRI OF R T KNEE JOINTDegree centigrades: UsersuserPictures2013-02-15 14.08.28.jpgC: UsersuserPictures2013-02-15 14.11.41.jpgC: UsersuserPictures2013-02-15 14.09.42.jpg Fig ( 3 ) : There is grounds of extended chronic medullary bone infarct in metaphyseal part of thighbone and shinbone with features dual line mark with deficiency of internal hydrops and widening upto the subchondral home base with prostration of the articular border of thighbone. There is marrow hydrops in subarticular part of shinbone and thighbone. Rate 2 myxoid degenerative alterations are seen in the anterior horn of sidelong semilunar cartilage and posterior horn of median semilunar cartilage, break of normal additive uninterrupted low signal strength of anterior cruciate ligament with partial break of fiber at tibial and femoral fond regard.MRI OF LEFT KNEEDegree centigrades: UsersuserPictures2013-02-15 14.11.41.jpg C: UsersuserPictures2013-02-15 14.12.39.jpgC: UsersuserPictures2013-02-15 14.12.06.jpg Fig ( 4 ) : There is grounds of extended chronic medullary bone infarct in metaphyseal part of thighbone and shinbone with features dual line mark with deficiency of internal hydrops and widening upto the subchondral home base with prostration of the articular border of thighbone. There is marrow hydrops in subarticular part of shinbone and thighbone. Tear of anterior horn of median semilunar cartilage. Modrate joint gush predominately in supra patellar pouch.MRI of BRAIN:Brain parenchyma shows normal MR morphology and grey white distinction, there is no focal parenchymal lesion. Basal gangia and thalmi are normal in volume and signal strength. Mid encephalon, Ponss, and myelin are cardinal and appear normal in signal strength. The cerebellar hemisphere are normal. Ventricular system are normal. WHOLE BODY BONE SCANC: UsersuserPictures2013-02-20 10.23.45.jpg Degree centigrades: UsersuserPictures2013-02-20 10.23.29.jpg Fig ( 5 ) : Skeltal scintigraphy done with20mci of 99m Tc-MDP endovenous and graph taken in three stages post injection revels. ( 1 ) : Flow stage ( immediate station injection ) : there is addition flow in part of bilateral articulatio genuss articulation ( 2 ) : Blood pool stage ( 5 min station injection ) : there is pooling in the part of bilateral articulatio genuss articulation ( 3 ) : Delayed stage ( 3 hour station injection ) : there is increase tracer uptake in the part of bilateral articulatio genus articulation, distal shaft of bilateral thighbone, proximal shaft of bilateral shinbone Suggestive of: -non specific arthritis bilateral articulatio genuss joint with infarct in distal shaft of bilateral thighbones and proximal shaft of bilateral shinbone.PreventionAt the present, there is no known bar but we can decrese the opportunity of AVN by extinguishing the hazard factors. Avoid Immuno-suppressants and other drugs such as Steroids, Glucocorticoid, Indocin, and Butazolidin and drugs that prevent the loss of bone mass such as Bisphosphonate ( diphosphonates ) .Foods that are good and nourish castanetss contain Calcium, Magnesium, Vitamin C and Vitamin D.TreatmentThe end in this instance is to better the map and to look into farther harm to the bone so that bone and joint survived. Without intervention, most people with the disease will see terrible hurting and restriction in motion. To find the most appropriate intervention, the physician considers the followers: the age of the patient, the phase of the disease ( early or late ) , the location and whether bone is a ffected over a little or big country, the underlying cause of osteonecrosis. The articulatio genus is the 2nd most common location for osteonecrosis after hip. The disease can be classified into 4 phases — phase I: patterned advance from no radiographical findings ; phase II: a little flattening of a the median condyle ; phase Three: visual aspect of a radiolucent lesion: and present IV: articular gristle prostration. There are two typical entities: ( I ) self-generated osteonecrosis of the articulatio genus ( SPONK ) , and ( two ) secondary osteonecrosis of the articulatio genus. They are differentiated by age of presentation, associated hazard factors ( e.g. usage of corticoid and alcohol addiction ) , location, lateralization, and condylar engagement. First stop hazard factors i.e. corticoid or intoxicant usage, intervention may non work unless usage of the substance is stopped. Early infarcts ( before X ray alterations are apparent ) can be treated with a surgical process called nucleus decompression and bone grafting or autologous bone marrow organ transplant to better circulation of affected country, but one time the condyle has lost its contour, nucleus decompression will non assist in hurting alleviation and farther prostration of the weight-bearing zone. The of import end to accomplish at this phase is the immobilisation of the affected country. Early Reconstruction, with debridement of the necrotic zone and replacing of the dead bone with autologous bone reinforced to back up the subchondral bone at hazard of prostration. Later phases of avascular mortification ( when X ray alterations have occurred ) necessarily advancement to a earnestly damaged bone and/or articulation that require arthroplasty or joint replacing surgery.DISCUSIONOsteonecrosis has been reported during or after the class of steroid intervention in several conditions such as reaping hook cell disease, systemic lupus erythematus, ulcerative inflammatory bowel disease and Crohn 'sdisease. Corticosteroids are believed to heighten the microvascular ischaemia by diminishing bone blood flow along with increased bone marrow force per unit area due to intra medullary lipocytes hypertrophy. The status can attest itself anyplace in the skeletal system, most normally in the femoral caput, but similar alterations have been reported in the distal articulatio genus, proximal shinbone, humerus, cubitus and the pes. No clear cut regulations exit sing the dosage and continuance of corticoid intervention followed by manifestation of osteonecrosis. Reported instances have documented it every bit early as 6 months to every bit tardily as three old ages. On carnal theoretical account it is reported to be found one hebdomad after the initial steroid disposal. Osteonecrosis begins perniciously and frequently the diagnosing is easy missed and delayed due to often normal field radiogram in early portion of the disease even in the presence of pathological alterations. MRI has bee n reported to be more sensitive and specific to observe osteonecrosis in an early stage. In diagnostic patients with negative field radiogram or MRI findings, the radionuclide bone scan is recommended. It is extremely sensitive for showing the countries of enhanced focal consumption before the alterations are evident on other imaging modes. Conservative intervention options including anodynes, braces, reduced weight bearing, bed remainder, deep heat modes and ROM exercisings are offered, but nil has been proved to be of much significance besides offering a impermanent diagnostic alleviation. None of the intervention options are believed to change the class of the disease. If diagnosed at an early phase, prostration of the subchondral bone and patterned advance of the disease may be averted in some patients by diminishing the joint emphasis and by developing mobility. Different surgical attacks including nucleus decompression, curettement, and bone graft have been tried with contradi ctory out comes, nevertheless, the ultimate intervention is frequently a joint replacing in badly involved articulations.DecisionIt is a common complication in patients with a history of anterior articulatio genus hurting of long continuance with history of injury or associated with other hazard factors of osteonecrosis genrally short-run or long-run corticoid. These instances are really hard to name initial phases with simple conventional imaging techniques. A careful scrutiny with high index of intuition is indispensable while covering with patients with anterior articulatio genus hurting. MRI and radionuclide bone scan are helpful in observing a field radiogram negative lesion. After clinical and radiological rating and verification of such lesion that affect the 2nd most common site after hip i.e. articulatio genus should be managed after proper theatrical production, taking to accomplish hurting free articulatio genus motion with non further deterioting the articulatio genus ma p and to better the morbidity of patient life.

Practical Psychology for Everyday Life

Practical Psychology for Everyday Life Question 1 I think one of the most important concepts I learnt from the lecture is the effect and influence of the non-verbal behaviors and language, but the people mostly lack of awareness on them and create misunderstanding even discontent among all of us. These non-verbal behaviors seem to be non-significant in our everyday life, but they do play a key role in daily communication. Even though non-verbal communication could only express simple thoughts and feelings, it indicates the true ideas and emotions.As verbal language sometime different from what we really think, for example, lying and overstating are typical models, these behaviors build up more barriers and obstacles between peoples. Thus, understanding of these non-verbal behaviors helps us express us more clearly and beneficial for our relationships. Non-verbal behaviors appear everywhere, every moment; even though they are common, but we did not pay much attention. And it leads to mismatch of verbal and non-verbal behavior creating ambiguity, the original idea could not be sent.In the past, when I was talking to others, I used to look at anywhere but not the one I was chatting with, no matter teachers or classmates. Because of this strange behavior, I was viewed as an ill-mannered student. It took me years to realize and solve it. In this situation, even though I thought I was talking with my teachers with the most polite language I knew, but my non-verbal behavior crumbled it. It is also a typical problem nowadays youth might have, as electronic gadgets become part of our life, most of us may focus on the smartphone in hand but not the friends around.Thus, the non-verbal behaviors reflect our manner, but lack of attention of these behaviors would be a worrying trend. Moreover, the non-verbal behaviors are indicators of our true feelings. In the past I wondered that how my sister could catch me when I was lying all the time. But later on, I discover that when I tell lies, I often shake my head. If we take a closer look to these minor behaviors, it would be easier to find others’ true feelings and what they try to hide. It is also eneficial for our daily communication. All in all, the non-verbal behavior should match with the verbal language, if we want to express ourselves to other, so other would get our ideas clearly, it avoids the unnecessary arguing and guessing and helps us contact with others more efficiently. Thus, non-verbal behavior should be taken a higher level of consideration. (Words for Q1: 420) Question 2 Self-discrepancy could be varies as three major self- perceptions: actual self, ideal self and ought self.This divergence defines us and shapes our personality as we seek unity of these three perceptions. The actual self represents the true qualities we acquired and what we really are. Despite this, some of us may omit it and pursue the ideal self, the ultimate qualities we desire. Besides that, ought self indicat es the qualities that we should grab. Inspired by my mum, a lady who strongly influenced by the traditional ideas. Once suffered in the mismatch of ought self and actual self. She married a man who did not love her, leading to another unfortunate marriage.This man gambled and lost my mum’s hard-earned money, he get drunk every night and creating more domestic-violence. In this circumstance, it is definitely that she should seek help and leave him. But in the struggle between her actual self – the desire to leave and ought self – the responsibility of a wife, her wavering brings more pain and sadness. In this case, the actual self of my mum falls short of her ought self, mixing the influence of the tradition ideas, she feels guilty when she tried to leave him.Besides that, the guilty remains even she left him for years, it lowers her self-esteem and makes her more fragile. From my mum’s experience, it reflects that the diversity between ought self and actu al self can be deeply affect and change one’s life. Apart from the ought self, the ideal self seems to be the ultimate goal of one’s actual self, but everyone has their own limit. In the past, I was forced to learn how to play piano because of my mum’s will. It was a difficult time for me as I found that I had no interest on piano or other instruments.In fact, I did try my best at the very beginning, but my fingers refused to dance on the piano keys but stomped on it. Later on, my mum started pushing me to play piano day by day, but the result just disappointing as usual. After several months, the monthly-long unsatisfactory outcome depressed me, at the same time, my academic results was declining as well. It illustrated the consequence caused by actual self fails to catch up with ideal self. Thankfully, my class teacher discovered it and discussed it with my mum, the piano measure was lifted and everything was back to normal.Thus, the objective we establish sho uld be achievable and relevant with our own abilities and our actual self. The draw-backs of forcing yourself to do impossible tasks could be unrecoverable. In conclude, understanding of self is the prerequisite for success, even though the desires and obligations may affect us. With the acknowledgement of ourselves, we erase our anxiety and take the duty. We find what our limits are and accept it and it pave the way to success. (Words for Q2: 488)